Additional boost needed to improve research performance is likely to come from combining data from different laboratories to overcome the limitations of individual approaches. Perspective: A greater involvement of the scientific community, with an increase in the scientific production related to Sigma-1, is desirable. High-frequency terms in author keywords suggest that the research efforts in some areas such as neuroimaging, cocaine addiction or psychiatric disorders have declined over time, while others such as neurodegenerative diseases or pain are currently most popular. Cluster labeling from author co-citation analysis shows that research has been focused on specific diseases such as addiction, neuroprotection and neurodegenerative diseases, psychiatric disorders, and pain. The article by Hayashi-T and Su-TP in Cell (2007) describing the Sigma-1 receptor as a chaperone protein is the top cited reference. Hayashi-T, Su-TP and Bowen-WD showed the highest citations per article. The top authors in number of publications were Wünsch-B, Schepmann-D, and Maurice-T. The leading institutions were the University of Münster, the National Institutes of Health, ESTEVE, and INSERM. The highest citation/article ratio was reached in France, United States, and Canada. Spain, Japan, and Italy showed the highest per million inhabitants ratio. The United States was the country with the highest production followed by Japan and Germany. The authors appear grouped in relatively independent clusters, thus suggesting a low level of collaborations between those dedicated to the Sigma-1 receptor. Only 247 authors have five or more publications. The growth in the production of articles is not constant over time, with periods of stagnation of approximately 5 years. Results: In total, 1,102 articles from 1992 to 2017 were identified. Methods: We used bibliometric indicators of a basic nature as well as techniques for the visualization and analysis of networks of scientific information extracted from Scopus database. This article aims to present a global view of Sigma-1 receptor research and its intellectual structure. Purpose: There are previous reviews focused on Sigma-1 receptor but no bibliometric studies examining this field as a whole.
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